Chronic fatigue syndrome/myalgic encephalopathy in children

Chronic fatigue syndrome/myalgic encephalopathy (CFS/ME) in children is a common condition associated with considerable controversy with reference to terminology, case definition, aetiology, treatment and prognosis. This frequently results in patients and families receiving mixed messages, and significant delay in establishing a diagnosis and receiving an appropriate management programme. We review current understanding and draw attention to the best practice approach to assessment, diagnosis and management of CFS/ME in children. This, we hope, will improve planning, organization and delivery of a patient-centred, optimized and clinically-effective multidisciplinary management strategy towards children with CFS/ME.