Viral hepatitis in children: what do we know in 2021?

Published:October 24, 2021DOI:https://doi.org/10.1016/j.paed.2021.09.002

      Abstract

      Viruses are a common cause of hepatitis in children. Hepatitis A and E cause acute infections while Hepatitis B, C and D can lead to chronic infection with increased morbidity and mortality due to chronic liver disease and hepatocellular carcinoma in later life. Acute infections may be fulminant causing acute liver failure necessitating a liver transplant. Our understanding of these viruses continues to evolve, and this review aims to summarize the current strategies in diagnosis, prevention and use of anti-viral drugs to treat these infections.

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      References

      1. Global hepatitis report. WHO, 2017
      2. Global health sector strategy on viral hepatitis, 2016–2021: towards ending hepatitis. World Health Organization, Geneva2016
      3. Public health control and management of hepatitis A, 2017 guidelines, Public Health England. Public health control and management of hepatitis A (publishing.service.gov.uk) https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/727411/Public_health_control_and_management_of_hepatitis_A_2017.pdf (accessed on July 14 2021).

      Further reading

        • Abdel-Hady M.
        • Kelly D.E.D.S.
        • Kuipers E.J.
        Hepatitis B and C in children in: encyclopaedia of gastroenterology 2nd edition. vol. 3. 2019: 113-121
        • Dalton H.
        • Webb G.
        Hepatitis E: an underestimated emerging threat.
        Ther Adv Infect Dis. 2019; 6: 1-18
      1. HCV Guidance: Recommendations for Testing, Managing, and Treating Hepatitis C https://www.hcvguidelines.org/.

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