Interpreting abnormal liver tests: a cased-based discussion

Published:November 11, 2021DOI:https://doi.org/10.1016/j.paed.2021.10.001

      Abstract

      Elevated liver enzymes are commonly seen by paediatricians in clinical practice. For many clinicians, interpreting deranged liver enzymes can be challenging. There is a lack of an evidence based approach to this. Alterations in liver enzymes may be a normal physiological response to an intercurrent illness or in certain cases may also reflect an underlying liver condition. In this review, we will aim to provide, through a series of cases, a guide on the approach of deranged liver enzymes to conditions that health care professionals may ‘commonly’ encounter.

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      Further reading

      Biliary atresia

      1. .

      Autoimmune hepatitis

      1. Diagnosis and Management of Pediatric Autoimmune Liver Disease: ESPGHAN Hepatology Committee Position Statement.

      Wilson's Disease

      1. Wilson’s Disease in Children: A Position Paper by the Hepatology Committee of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition.